The best window of optimize treatment is  inpatiient period,immediately after relief symthoms of acute heart failure .even for some new medications it is possible to begin in acute setting,for instance SGLT2 inh.do not impact blood pressure significantly and from my point of view looks like drugs which can be used as "fire and do not worry".In generally all drugs were prescribed in hospital in acute phase associates in pts with relief of symptoms,therefore patient likely will be more adherent to the medicines were prescribed in a hospital.But in generally,the best window to optimize therapy is everytime in meaning that for to reach GDMT goal we have to be in contact with patient as often as possible.